Throughout evolutionary history, life has explored the laws of physics, creating remarkable new strategies to perpetuate itself. We are a research group in the Departments of Biology and Physics and a part of Boston University’s Biological Design Center that seeks to understand how these strategies arise using microbial populations as a model. We are interested in how the physical and chemical environment influences microbes, and how these microbes in turn engineer that very environment. In particular, we study how bacterial biofilms change their local conditions by producing extracellular matrix and how cell-to-cell signals drive such behaviors. We probe theoretical models of these phenomena with the goal of building toward an emergent understanding of life.
Our group also has specific interest in how electrophysiology influences the behavior of bacteria, including through cell-to-cell communication, and control of both metabolism and gene expression.
To investigate these problems, we use time-lapse imaging and custom experimental devices to observe and probe microbial behaviors in space and time.